Acute ankle sprain in athletes: Clinical aspects and algorithmic approach

Author contributions: Halabchi F and Hassabi M contributed equally to this work; both authors contributed to all stages of the development of this manuscript from planning the structure, searching evidence, editing and revising the main text, preparing original photos, and the algorithm; both authors have read and approved the final manuscript.

Corresponding author: Mohammad Hassabi, MD, Assistant Professor, Department of Sports and Exercise Medicine, Shahid Beheshti University of Medical Sciences, Aarabi Avenue, Yaman Street, Tehran 19979-64151, Iran. ri.ca.umbs@ibassah

Received 2020 Feb 25; Revised 2020 Oct 4; Accepted 2020 Oct 23. Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

Abstract

Acute ankle sprain is the most common lower limb injury in athletes and accounts for 16%-40% of all sports-related injuries. It is especially common in basketball, American football, and soccer. The majority of sprains affect the lateral ligaments, particularly the anterior talofibular ligament. Despite its high prevalence, a high proportion of patients experience persistent residual symptoms and injury recurrence. A detailed history and proper physical examination are diagnostic cornerstones. Imaging is not indicated for the majority of ankle sprain cases and should be requested according to the Ottawa ankle rules. Several interventions have been recommended in the management of acute ankle sprains including rest, ice, compression, and elevation, analgesic and anti-inflammatory medications, bracing and immobilization, early weight-bearing and walking aids, foot orthoses, manual therapy, exercise therapy, electrophysical modalities and surgery (only in selected refractory cases). Among these interventions, exercise and bracing have been recommended with a higher level of evidence and should be incorporated in the rehabilitation process. An exercise program should be comprehensive and progressive including the range of motion, stretching, strengthening, neuromuscular, proprioceptive, and sport-specific exercises. Decision-making regarding return to the sport in athletes may be challenging and a sports physician should determine this based on the self-reported variables, manual tests for stability, and functional performance testing. There are some common myths and mistakes in the management of ankle sprains, which all clinicians should be aware of and avoid. These include excessive imaging, unwarranted non-weight-bearing, unjustified immobilization, delay in functional movements, and inadequate rehabilitation. The application of an evidence-based algorithmic approach considering the individual characteristics is helpful and should be recommended.

Keywords: Ankle sprain, Rehabilitation, Athlete, Sport injury, Return to play, Exercise therapy

Core Tip: Acute ankle sprain is the most common injury in athletes. Several interventions have been recommended in the management of acute ankle sprains, among them exercise and bracing have been recommended with higher level of evidence and should be incorporated in the rehabilitation process. An exercise program should be comprehensive and progressive including range of motion, stretching, strengthening, neuromuscular, proprioceptive and sport-specific exercises. The application of an evidence-based algorithmic approach considering the individual characteristics is helpful and should be recommended.

INTRODUCTION

Acute ankle injury is one of the most prevalent musculoskeletal injuries[1,2]. Ankle sprain is the most common lower limb injury in physically active individuals[3,4]. Each day, almost one ankle sprain occurs per 10000 persons in Western countries[1,5] and over two million ankle sprains are treated annually in emergency departments of the United States and United Kingdom[6]. In sport, the incidence is even higher, accounting for 16%-40% of all sport-related trauma cases[1,7,8].

Approximately 40% of all traumatic ankle injuries and nearly half of all ankle sprains occur during athletic activity[4,9,10], with basketball (41.1%), American football (9.3%), and soccer (7.9%) having the highest incidence[4,6,11]. Ankle sprain is more prevalent in females, children, and athletes taking part in indoor and court sports[9].

Besides the bony and muscular structures, several ligaments have a major contribution to the stability of the ankle joint, which are distributed in lateral, medial, and syndesmotic areas (Figure ​ (Figure1 1 ).

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Lateral ligaments of the ankle.

Almost 85% of ankle sprains involve the lateral ligaments. In about 65% of cases, isolated injury of the anterior talofibular ligament (ATFL) and in 20%, injury of both ATFL and the calcaneofibular ligament exist. Injuries of the posterior talofibular ligament are unusual[12]. The remaining 15% involves syndesmotic and medial ankle sprains[9]. A syndesmotic ankle sprain is an injury to one or more of the ligaments comprising the distal tibiofibular junction and is frequently known as "high ankle sprain"[10].

Despite its excessive prevalence, the long-term prognosis of an acute ankle sprain is not favorable and a high proportion of patients experience persistent residual symptoms (up to 40%-50%)[13,14] and injury recurrence[6]. Furthermore, the prevalence of underdiagnosed injuries associated with ankle sprain, such as tendinous and osteochondral injuries and midfoot fractures are high[15]. Therefore, direct and indirect financial and societal costs for managing lateral ankle sprains and their sequelae lead to a high socioeconomic burden[10,16,17].

In this review, we aimed to discuss different clinical aspects of lateral ankle sprain in athletes and introduce a novel and practical algorithmic approach for proper diagnosis and management.

RISK FACTORS

Several parameters have been suggested as potential risk factors for ankle sprain. These are classified as intrinsic or extrinsic. Some of the intrinsic risk factors are modifiable and their identification may be helpful in the prevention of potential injury[18].

Several studies have investigated proposed risk factors in athletic and military populations. These include demographic (including age[19], gender[20], weight[19-22], height[20,21], body mass index[20,21,23,24], limb dominance[20]), anatomical (foot type[20], foot and ankle alignment, including foot hyper-pronation)[20,21], laxity (generalized joint laxity[20,21,24], ankle-joint laxity[19-21,24]), range of motion (ROM), including ankle and first metatarsophalangeal ROM[21,24-27]), muscle strength[19,20,23,26,27], muscle-reaction time[20,23,24], balance (single leg balance and star excursion balance tests) and proprio-ception[20,21,23-26], previous history of ankle sprain[11,21,22,24,25], and sport-related parameters (including type of sport[25], level of competition[25], playing on artificial grass[25], playing position[25], type of sport shoe[11], lack of warm-up stretching[11], and landing technique after a jump[25]). There is no convincing evidence on how significant or effective these parameters are. However, previous history of an ankle sprain, being overweight, ankle joint laxity, and impaired balance are some exceptions that the majority of studies have agreement on their importance[11,20-22,24,25,28]. For example, it has been shown that an overweight player with a previous ankle sprain is 19 times more likely to sustain noncontact ankle sprain compared to a normal-weight player with no previous ankle sprain[22].

CLINICAL PRESENTATION

History

Accurate clinical assessment of the ankle injury needs a comprehensive and organized history[29]. Athletes usually report shifting the center of gravity over the lateral border of the weight-bearing leg as an injury mechanism. It may be caused by catching the lateral side of the foot on the ground, awkward landing on the opponent's foot, or contacting with the inside of the opponent's supporting leg during a slide tackle[30,31]. The patients typically complain of lateral ankle swelling (local or diffuse), pain, bruising, and limited ROM[32]. The ability of weight-bearing immediately after injury is important and may influence the decision to order standard radiology[33].

History must also include age, demographic data, time since injury, exact mechanism, nature of injury (acute or chronic), location of pain, previous history of ankle sprain or instability, history of other lower extremity pain or deformities, mechanical symptoms (locking or feeling of loose bodies) and paresthesia[33-36].

In the case of a suspected ankle sprain, the physician should probe risk factors such as previous injury, special activity, or sport during which the injury occurred, footwear, playing surface, and the use of taping or bracing[33].

Usually, plantar flexion and inversion of the ankle is the main mechanism of lateral sprain[33]. A history of other mechanisms (e.g., forced plantar flexion, eversion, and dorsiflexion) should alert the physician about uncommon ligament injuries or fractures[37].

Physical examination

After looking for a fracture by careful palpation of the critical anatomic check-points (especially lateral and medial malleoli, the base of the fifth metatarsal and navicular bones), ecchymosis, edema, point tenderness, ROM, ligamentous laxity, and muscle strength should be carefully evaluated in all suspected ankle sprains[1,32,36,38,39].

In a typical lateral ankle sprain, ecchymosis and tenderness are located over the ATFL and calcaneofibular (CFL) ligaments. Acute injuries do not have swelling or ecchymosis over the forefoot or toes. However, in the absence of appropriate treatment and after one day, bruising and swelling may be visible down the whole foot as a result of gravity, especially if the patient has been ambulating[37]. Edema may be measured with a tape using a figure of 8 method that includes four points of lateral and medial malleoli, the base of the fifth metatarsal and navicular bone[40]. Evaluation of active, passive, and resistive ROM can help to differentiate injury to ligaments, tendons, muscles, and nerves (level 3)[41]. Also, a typical antalgic gait to protect the ankle and avoid further pain is common[7].

The provocative tests are also important. Anterior drawer and talar tilt (inversion stress) tests are utilized to evaluate lateral ankle instability. These tests should be performed in comparison with the uninjured ankle. Tests are regarded as positive in cases of increased laxity[1,39].

The anterior drawer test (ADT) is applied to assess the integrity of ATFL as it prevents anterior translation of the talus under the distal tibia. Ten millimeters of displacement in the injured ankle or more than 3-4 mm of difference in translation compared with the healthy side indicate an ATFL tear[7]. In an ATFL tear, a dimple sign may also be visible in the anterior side of the joint in 50% of cases[42].

The talar tilt test evaluates the integrity of the CFL. In this test, the angle between the talar dome and the tibial plafond is measured during forced heel inversion while the tibiotalar joint is in the neutral position. If there is more than 5° of difference with the normal side, the test is considered positive[7].

It should be noted that during the few days after injury, in the acute condition (especially when joint effusion has occurred), the physical examination may be nonspecific due to pain and swelling[36]. Therefore, all patients should be examined again 3-5 d later[43]. It was demonstrated that the ADT in this delayed examination produced the best results in comparison to stress radiography, sonography, and arthrography with a sensitivity of 96% and a specificity of 84% (level 2)[10,43].

To rule out less common syndesmotic injuries, provocative tests are helpful. These tests including the squeeze test (lower leg squeeze at midcalf), crossed-leg test (asking the individual to cross the legs with the injured leg resting at midcalf on the other knee), external rotation stress test (concurrent external rotation and dorsiflexion), heel thump test (applying gentle but firm thump on the heel with the fist) and Cotton test (applying a medial and lateral translation force to the foot) to stress the syndesmosis and elicit pain above the ankle joint[37]. Otherwise, swelling and tenderness on the medial side of the ankle, positive eversion stress test, and/or defect palpation in the soft tissues just distal to the medial malleolus may suggest probable deltoid ligament injury[7].

Assessment of the patient’s neurovascular status in the injured extremity should also be included as an essential part of the physical examination[7]. For this purpose, light touch sensation, capillary refilling, and dorsal pedal pulse should be checked[31].

In the sports setting, the sports-specific functional level of the athlete should also be assessed. Proper objective interpretation of these findings is fundamental to correct injury grading[38].

Grading

Lateral ankle sprains are characteristically classified as grade I, II, or III, based on the severity of injury to the lateral ligaments. As mentioned earlier, provocative ligament tests are challenging to accomplish at the time of acute injury; thus, clinical grading is usually rather subjective and focused on the amount of existing swelling, pain, and ecchymosis[37].

Mild swelling, tenderness, and minimal difficulty in ROM are usually seen in lower grades. However, diffuse swelling, ecchymosis, tenderness, positive provocative tests, and inability of weight bearing are associated with substantial instability in a Grade III injury. Hemarthrosis may also complicate the clinical presentation[7].

According to a systematic review, 96% of patients with all four findings of swelling, ecchymosis, tenderness and a positive ADT have a lateral ligament rupture in contrast to only 14% of individuals without all these findings[44].

There is no definite end-point for unilateral joint laxity in the ADT or talar tilt test suggesting grade III injuries[44]. Therefore, due to this problem as well as limitations imposed by pain and dysfunction, precisely recognizing grade III sprains is clinically difficult[45].

A grading system has been introduced in which more severe grades need longer rehabilitation for full recovery of the athlete[32,38] (Table ​ (Table1 1 ).

Table 1

Ankle sprain grading system[32,38]

Grade Hemorrhage Point tenderness Loss of function Decreased total ankle motion Swelling Anterior drawer test Talar tilt test Stress radiography
ILittle or NoNoNo≤ 5°≤ 0.5 cm ---
IIYesYesSome> 5° and < 10°> 0.5 and < 2 cm+--
IIIAYesYes (extreme)Near total≥ 10°≥ 2 cm++ADM ≤ 3 mm
IIIBYesYes (extreme)Near total≥ 10°≥ 2 cm++ADM > 3 mm

ADM: Anterior drawer movement.

This grading system can estimate the severity of an injury and predict the prognosis[38]. However, clinical grading does not change initial management and has a limited role in the acute setting[37].

IMAGING

Plain radiography

The Ottawa Ankle and Foot Rules are clinically recommended for all acute ankle injuries in order to accelerate patient care and reduce the number and costs of unnecessary radiographs[46-48].

According to these rules, plain ankle radiography is needed, if pain exists in the malleolar zone and there is at least one of the following signs: (1) Bone tenderness in the distal 6 cm of the posterior half of the tibia or tip of the medial malleolus; (2) Bone tenderness in the distal 6 cm of the posterior half of the fibula or tip of the lateral malleolus; and (3) Inability of weight-bearing for 4 steps both immediately after injury and in the physician’s office or emergency department.

In addition, if the midfoot is painful, plain foot radiography should be requested if any of the following exist: (1) Inability to bear weight for 4 steps just after the injury and at the medical service center or office; (2) Tenderness over the navicular bone; and (3) Tenderness at the base of the fifth metatarsal bone[37,48].

These rules are the most validated tool for exclusion of ankle or mid-foot fractures in first 7 d after injury (level 1)[46-48]. Multiple studies have shown a high sensitivity of 94.6% to 100%, but a variable specificity, ranging from 11.5% to 79%, in detecting fractures in adults and children with acute ankle injury[36,44,47,49,50].

As a result, negative findings indicate that radiography is not needed. Nevertheless, due to low specificity, positive findings do not essentially reveal the existing fracture, but do show that radiography is required to approve or rule out fracture[48].

If ankle radiographs are indicated, standard trauma views including anteroposterior (AP), mortise (AP with 10°-20° internal rotation) and lateral views should be obtained[1,48]. Imaging during weight-bearing would be ideal; however, the patient's tolerance and cooperation in the acute phase may be challenging[7,36].

In the case of tenderness on the proximal part of the fifth metatarsal, an oblique foot X-ray may also be necessary. AP and mortise views in ankle dorsiflexion and plantar-flexion may also be valuable in suspected osteochondral lesions of the talus[7].

In a skeletally immature patient, Salter-Harris type 1 fracture should not be overlooked, when there is tenderness over the distal growth-plate of the tibia or fibula[31].

Stress radiography

Ankle stress radiography is generally unnecessary, unreliable, and outdated to reveal acute ligamentous injuries after ankle sprain (level 2)[1,41,51].

The technique is painful and needs local anesthesia. The result is also inconclusive due to high variability in values defined as normal as well as mechanical or manual techniques to achieve optimal stress[1].

Two types of stress radiography may be used, which generally aid in the diagnosis of medial or syndesmotic ligament injuries: (1) Talar stress views may be helpful to detect lateral instability by taking an ankle mortise view while locating the ankle in plantarflexion and inversion; and (2) External rotation stress views may be used to diagnose the syndesmotic or deltoid ligament injuries. In this view, the ankle is forced to external rotation while obtaining an AP view. Increased medial clear space width (space between the medial malleolus and talus) of more than 4 mm is indicative of deep deltoid ligament rupture and tibiofibular clear space (measured 1 cm proximal to the tibial plafond) of more than 6 mm in both the AP and mortise views suggests syndesmotic injuries[52].

Ultrasound

Ultrasound may be useful for the diagnosis of ankle ligamentous injuries. Diagnostic accuracy of up to 95% for ATFL and 90% for CFL injuries has been reported for ultrasound[53]. Additionally, ultrasound permits the physician to obtain dynamic images to detect functional impairments or joint instability that could not be visualized with other imaging choices[7,53].

Nevertheless, it has two notable limitations: First, acute tears may be pictured in different forms such as hypo-echogenicity or swelling, which may not provide adequate information for correct diagnosis, and second, its accuracy is highly dependent on the operator and/or equipment.

Compared with magnetic resonance imaging (MRI), diagnostic ultrasonography is valuable but less precise and sensitive in the detection of acute lateral ligament injury (level 2)[41].

MRI

Despite the fact that MRI is a reliable method for revealing acute tears of the ATFL and CFL following acute injury (level 2)[41], it is not usually indicated in the routine investigation of acute ankle injuries due to high incidence, limited accessibility, high cost and false-positive findings[1].

However, as the gold standard imaging modality of ankle ligamentous and intra-articular injuries[1], MRI may be extremely beneficial in some particular patients with clinically suspected concomitant injuries, such as osteochondral lesions, syndesmotic injuries, and tendinous pathologies or when persistent symptoms and chronic ankle instability mandate further workup[33].

MRI has good accuracy to detect osteochondral lesions of the talus and determine the level of injury to the ankle syndesmotic ligaments (level 2)[41].

Other imaging techniques

Other techniques such as computed tomography (CT) scan, CT arthrogram, contrast-enhanced MRI, magnetic resonance arthrogram or bone scan are not routinely ordered for diagnosis. However, they may be valuable in the assessment of particular patients[7]. Arthrography within 48 h after an inversion trauma is highly sensitive, but not recommended (level 2)[25].

TREATMENT AND REHABILITATION

Rest, ice, compression, and elevation

Similar to many acute musculoskeletal injuries, the principles of rest, ice, compression, and elevation (RICE) are historically applied for patients with ankle sprain. However, there is limited evidence supporting the efficacy of this approach in reducing associated symptoms following injury[10,33]. Several studies have investigated the components of ice and compression[10].

Limited evidence has indicated that the effectiveness of cryotherapy for reducing symptoms of an ankle sprain is doubtful (level 1)[10,54,55]. Also, there is no evidence that the isolated application of ice can decrease pain and swelling, as well as improve function among persons with acute ankle sprain (level 2)[10,56,57]. However, cryotherapy for 3-7 d is routinely used to reduce pain, minimize swelling and bleeding due to vasoconstriction (especially when applied in the first hours), and decrease secondary injury[54,56,58].

Most statements have recommended a protocol of 20 min each two hours[59]. Intermittent immersion cold therapy in the first week after injury may also be helpful in short-term pain relief[38,56,59].

Due to lack of evidence and the potential for injury exacerbation as the result of vasodilation and inflammatory response, thermotherapy (application of heat) is not recommended during the acute and subacute phases of injury (level 3)[41,57].

Traditionally, compression is regarded as an effective tool to reduce swelling and improve quality of life[60], but current evidence concerning the effectiveness of compression after acute sprain is questionable (level 2)[10,61-64]. It may be explained by the poor quality of existing studies and the variety of treatments used. However, over 75% of hospitals still use tubular compression bandaging despite the lack of convincing evidence on its effectiveness at enhancing recovery[60]. Nevertheless, the application of an elastic bandage in acute ankle sprain was more effective than a splint in reducing edema. Therefore, an elastic bandage could be preferred over a splint for the treatment of acute ankle sprains[65].

There have been no controlled trials on the individual efficacy of rest or elevation in the management of acute ankle sprains[33]. Nevertheless, the injured leg with an acute sprain may be elevated 15-25 cm above the level of the heart to enhance venous and lymphatic drainage and minimize swelling[41,59].

Although there is no sufficient evidence, the use of RICE therapy is a reasonable, routine, and probably safe method in the acute setting for short-term pain relief to expedite early mobilization[33].

Analgesic and anti-inflammatory medications

Nonsteroidal anti-inflammatory drugs: Oral and topical nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to decrease pain and inflammation in the acute phase of ankle sprain[66].

Current studies indicate that the consumption of topical or oral NSAIDs in young and healthy athletes cause short-term improvement of pain and swelling (< 2 wk) without considerably raising the risk of unfavorable events compared with placebo (level 1)[10,41,67-70].

Although NSAIDs are generally considered safe, they should be prescribed prudently due to their potential gastrointestinal, renal, and cardiovascular adverse effects (level 2)[10,71]. Otherwise, they may delay the natural healing process caused by inhibition of the normal inflammatory response[33,71]. Therefore, before prescription, their effect on each individual case has to be weighed.

Regarding the selected NSAIDs for ankle sprains, a few studies have shown superior results for diclofenac at first and second days compared with piroxicam and ibuprofen for pain reduction in mild to severe acute sprains and equal side effects (levels 2 and 3)[10,72,73].

Acetaminophen: Acetaminophen seems to be equally effective as NSAIDs for pain, swelling, and ROM in the first two weeks following acute sprain (level 1)[10,33,74-76].

Opioid analgesics: Compared to NSAIDs, opioid analgesics are similarly effective for pain control, albeit with more adverse effects (level 2)[10,77,78].

Other pharmaceutical agents: Besides the routinely used analgesics, other pharmaceutical agents were investigated in the management of acute ankle sprains, such as hyaluronic acid or platelet-rich plasma (PRP) injections and topical Traumeel. Studies have shown that periarticular hyaluronic acid injections compared with placebo decreased the pain, but they did not result in a faster return to sport or reduced recurrence (level 2)[10,79,80]. Orthobiologics such as PRP injections were not better than placebo injections for pain and functional outcomes (level 3)[10,81]. Also, topical Traumeel was not more effective than diclofenac topical gel for ankle swelling, pain, and function (level 2)[10,82].

Bracing and Immobilization

According to the current evidence, early mobilization and functional ankle support are better than rigid immobilization in the management of acute ankle sprains, especially for grade I and II injuries (level 1)[10,83].

A randomized controlled trial showed that injured athletes who used functional support were able to return to sports activities earlier than those who were managed by casting, and they had fewer symptoms 3 to 6 mo after injury. Although the re-injury rate between the two groups was not significantly different, more ligamentous laxity was radiographically observed among the athletes who were managed with the cast[84]. In a meta-analysis comparing rigid immobilization and functional support, authors reported that a higher percentage of patients who were treated with functional support returned to sports than those managed with rigid immobilization (level 1). Studies have also shown, at intermediate follow-up that the functional support group had benefited from a greater ROM, earlier return to work, and less prevalence of ligamentous laxity and persistent swelling[83,85-88].

However, some evidence showed that a short episode of immobilization (less than 10 d) with a below-knee plaster cast or rigid stirrup brace may be of added value in grade III sprains to decrease pain and swelling and improve functional outcome (level 2)[10,33,89-92].

Functional supports are frequently used in the form of a brace, tape, or elastic bandage. These external supports are different from rigid immobilization and permit loading on damaged tissues in a protected manner[91]. The use of an ankle brace shows the greatest effects compared with other types of functional support such as non-elastic sports tape or elastic kinesiotape, with no side effects (level 2)[10,93]. The superiority of different types of external supports over each other is a matter of controversy[85,94,95].

In comparison between the brace and elastic bandage, a meta-analysis demonstrated that lace-up or semi-rigid braces are superior to the application of the elastic bandage (level 1)[85]. Any type of true ankle support is more efficient than the less adequate supports such as compression bandage (level 2)[91]. Therefore, it seems that compression bandage is not beneficial after the acute phase in the management process (level 3)[64]. The use of an elastic bandage is associated with a delayed return to sport and more perceived instability compared to semi-rigid ankle support[85].

Although outcomes following six months treatment of acute ankle sprain shows no difference between managements with tape, semi-rigid brace, or lace-up brace, in the short-term a lace-up brace or semi-rigid brace appears to be more effective in reducing swelling than a tape or elastic band (level 2)[85,96]. In addition, bracing is more cost-effective[93].

A small systematic review has shown that kinesiotape may not provide adequate mechanical support for unstable ankles (level 1)[97].

However, the success of functional support depends on the severity of the injury. For instance, outcomes may be worse in a sprain complicated by an avulsion fracture, compared to isolated ligament injuries[10,98].

As a conclusion, a lace-up brace or a semi-rigid brace seems suitable and are recommended for all athletes with a prior history of ankle sprain, especially when participating in high-risk activities and sports[99], although some authors believe that lace-up ankle supports are superior to semi-rigid ones[100,101]. In elite athletes, taping can also be a choice[25].

A brace should be used for a minimum of 6 mo following an acute moderate to severe ankle sprain to prevent recurrence[102]. Apart from the preventive effect, the rate of severe ankle sprain is reduced with the use of brace[6,16].

Regarding the protective effect of external supports in athletes returning to the sport after an ankle sprain, a systematic review revealed that athletes who taped or braced had 70% fewer ankle injuries compared to individuals without any prophylactic support[103,104].

Weight bearing and walking aid

Despite the traditional emphasis on non-weight bearing in the early phases of rehabilitation, a systematic review has shown that early weight-bearing with support reduced the symptoms of acute ankle sprain[105]. This early and progressive weight-bearing should include a proper walking-aid device such as a crutch, as needed[106]. Numerous studies have demonstrated that integrating early weight-bearing and movement has a positive influence on the reduction of swelling and restoration of normal ROM. In addition, it accelerates the return to normal activity[105,107,108]. These positive effects have also been reported in individuals with severe grade III sprains, without impeding long-term mechanical stability[109].

Foot orthosis

Foot orthoses may have a significant positive effect in athletes with acute ankle sprain[110]. Some studies have shown that they considerably diminished pain and increased postural control after an acute ankle sprain, possibly due to improved sensory inputs and improved muscular function[110-112]. Both custom made and prefabricated orthoses seem to be effective. Currently, the use of foot orthoses is endorsed by some experts as an important part in the rehabilitation process of ankle sprain[104].

Manual Therapy

The application of manual techniques in the rehabilitation process of acute ankle sprains may be beneficial in pain reduction[113,114] (level 1), ROM (especially dorsiflexion, level 1)[113,115,116], stride length, and functional recovery[113,114]. However, it is uncertain whether manual therapy was useful for the primary outcome of recurrence rate[6].

Common manual techniques include anterior to posterior talocrural glides and talocrural distraction in the neutral position[113]. Soft tissue massage and manual lymphatic drainage techniques can also be performed to reduce stiffness and swelling while improving ROM and proprioceptive awareness[117].

The combination of manual therapy and exercise therapy may provide better results compared with exercise therapy alone (level 3)[114]. Mobilization with movement of the ankle joint includes a combination of posterior talar glide mobilization and active dorsiflexion and can be performed in both positions of weight-bearing or non-weight-bearing[118]. This method may be performed to further increase dorsiflexion and improve function (level 2)[41,118,119].

Accordingly, the inclusion of manual therapy techniques into rehabilitation programs is recommended (level 3)[10,33].

Exercise therapy

Growing evidence supports the use of exercise therapy as the main component of the treatment program[25,115,120-122]. The efficacy of exercise therapy programs has been established, especially when initiated early following an acute ankle sprain[10,120,123].

These programs can reduce the prevalence of recurrent injuries[115,124,125], as well as functional ankle instability[115,126]. Moreover, they may result in an earlier time to recovery and improved self-reported function following acute ankle sprain (level 1)[6,121,124,126].

Both supervised[121,122,127] and home-based[25] exercise are recommended. However, supervised exercise compared with home-based programs may be more helpful in improving ankle strength and proprioception[127], and returning to work[122] and sport earlier[121] (level 1). Nevertheless, some articles disagree with these positive results and believe that the addition of supervised exercise therapy may not be more effective than the conventional program alone (level 2)[115,128-130]. Accordingly, it remains uncertain whether exercise therapy should be supervised or not and additional research is necessary (level 1)[10].

Exercise therapy should be comprehensive and progressive and include ROM, flexibility (stretching), resistance (strengthening), neuromuscular and proprioceptive, and finally sport-specific functional exercises (level 2)[10,41,88,92,120,131-135]. However, no consensus exists regarding the optimal exercise content and training volume in this area[136].

ROM exercises: Early ROM exercises should be started as soon as pain permits[100]. Such a program can frequently be commenced immediately in grade I and II injuries but may need to be postponed in a grade III injury[35]. As soon as the pain permits, individuals should begin weight-bearing and ROM rehabilitation[37,100].

However, it is better to minimize inversion and eversion in the early stages of rehabilitation. After decreasing tenderness over the ligament, inversion and eversion exercises should be added. Athletes are encouraged to do these exercises slowly, without pain, and to use high repetitions[137]. ROM should be resumed first, before functional rehabilitation starts[138].

Stretching exercises: These exercises should be started with open-chain ankle motions for all planes and non-weight bearing dorsiflexion stretch with upper extremity assist and progress to standing calf stretch and generalized ankle stretching in the closed chain[138,139]. Vigorous heel cord stretching should be initiated as soon as possible. It is hypothesized that tight heel cord may act as a bowstring and can increase the possibility of ankle sprains[140].

Strengthening exercises: After restoration of normal ROM, the athlete starts this phase, beginning with isometric exercises against an immobile object in both frontal and sagittal planes. Afterward, the athlete progresses to isotonic resistive exercises using weights, elastic bands or manual resistance by the therapist for dorsiflexion, plantar flexion, inversion, and eversion as tolerated by pain. It is recommended to start with dorsiflexion and plantar flexion isotonic exercises in the early phases, which do not compromise the ligaments. As the ligaments heal further and ROM normalizes, strengthening exercises may be begun in all planes of motion, using pain as the basic guideline[137]. These combine concentric (muscle shortening), and eccentric (muscle lengthening) exercises[37,141]. At first, light resistance with high repetitions are recommended (two to four sets of 10 repetitions)[137]. Strengthening the peroneal muscles is important because reduced eversion strength has been associated with recurrent injury and chronic instability[35]. Bilateral standing toe raised through the full range with use of an angle board or stairs may also be helpful[139]. Proprioceptive neuromuscular facilitation (PNF) strengthening exercises that isolate the desired motions at the talocrural joint may also be useful[137].

As an athlete progresses through the program, it is essential to include exercises that involve proximal muscles of the hip and trunk. It has been shown that low hip strength may increase the chance of lateral ankle sprains[28]. Merging hip and trunk exercises in the rehabilitation process may be useful in reducing the re-injury rate and hence should be considered in athletes with acute ankle sprain[38].

Neuromuscular and proprioceptive exercises: The next phase of rehabilitation involves neuromuscular and proprioceptive training to restore the balance and postural control[133,142].

It was demonstrated that neuromuscular activation patterns are altered after ankle sprain, which may contribute to adverse outcomes such as functional instability, gait abnormalities, and increased recurrence rate[143]. Therefore, these exercises may reduce subjective instability, improve functional outcome measures[126] and decrease the prevalence of recurrence[115,124,126,144].

Early application of neuromuscular training in the first week of injury gives rise to higher activity levels without consequences such as increased pain, swelling, or the rate of re-injury[120]. Therefore, early neuromuscular re-training is safe and effective and is recommended as an important part of the rehabilitation program for athletes suffering ankle sprain[33,38,126]. This type of training should be performed throughout the rehabilitation process (level 1)[41,132-135].

In the early phases, neuromuscular (sensorimotor) exercises may be started with intrinsic foot motion (toe extension with ankle plantar flexion/toe flexion with ankle dorsiflexion) and exercises performed on a foam surface, wedge board, Bosu or DynaDisc in the seated position[133,142,145]. Initially, the athlete should begin with a wedge board in the sagittal direction. As pain decreases, the board may be turned in the coronal direction. When the athlete can perform these movements without difficulty, a seated Biomechanical Ankle Platform System (BAPS) board may be used for full ROM exercises[137,139].

When seated exercises are done easily, standing balance exercises should be started. They may be initiated on one leg standing without a board. The patient then supports their weight with the hands and maintains balance on an unstable surface of a wedge board in either the sagittal or coronal direction with both and then the injured foot. Next, hand support may be eliminated while balancing on the wedge board. The same sequence is then used on the BAPS board[137]. In athletes, the exercise may be made more challenging with the addition of sport-specific perturbation (depending on specific sport; chest pass/overhead pass, volleyball passing, hand fighting for football/wrestling). In the last phases, full-speed planned movement drills (Ladder, Cone) and unilateral jumps to unstable surfaces (foam pad/Bosu) should be performed[139].

Sport-specific exercises: The last phase of the rehabilitation process involves sport-specific training. In a volleyball player, it may consist of plyometric training with jumping maneuvers and for a soccer player, this would include running and cutting drills[146]. Application of a brace or tape may be warranted during the early period of sport-specific training[35].

Although there is no convincing evidence to support better results of sports-specific training compared to neuromuscular training with regard to reducing the chance of re-injury, it seems prudent, based on existing evidence, that sport-specific training be incorporated in the rehabilitation program of athletes with acute ankle sprain[38,106].

This phase of the training program needs expert trainers or therapists with equipment and facilities simulating the real sporting milieu. Evaluation of mastery in sport-specific skills mandates good interaction between the rehabilitation team so that the treating physician can decide regarding return to play[104,147].

Samples of different suitable exercises in the rehabilitation of acute ankle sprain are illustrated in Figure ​ Figure2 2 .